Summary: The tyrosine phosphatase STEP61 is the molecular brake that is lost to drive a coupling between KCC2-dependent disinhibition and the potentiation of GluN2B NMDARs in a pathological spinal mechanism that is conserved between rodent and human models of chronic pain. The ex vivo human BDNF model developed in this paper helps form a translational bridge between rodents and humans for identification and validation of novel molecular pain targets.
Chris will be presenting his work at CAN 2019. His work looks at the role of GluN2D function and modulation in spinal cord pain signalling. Check out his poster during Poster Session 2 on Friday May 24 from 3:30PM - 5:30PM.
Annemarie will be presenting her work at the APS Spring Pain Meeting in Milwaukee, WI. This year's meeting is centered around "Combating the Opioid Epidemic through Innovations in the Treatment of Pain". Annemarie's talk will be during Session 8: Translational Pain Models.
Place: Wisconsin Center, 400 W Wisconsin Ave
Mike will be speaking on the "Contributions of T-type channels towards spinal pain processing" at the Calcium Channel Network's triennial conference
Mike will be presenting at Carleton University's Science Cafe Seminar Series. For more information, see Carleton University's Science Cafe web-page.
Sunnyside Branch of the Ottawa Public Library at 1049 Bank Street
Come see Mike present on chronic pain and his current research at The Ottawa Hospital's Neuroscience Seminar Series.
University of Ottawa, Roger Guindon Hall, Seminar Room 1421
Annemarie Dedek presents her work at Carleton University's Neuroscience Colloquium Series. Her talk centered around the role of STEP61 as the molecular linker between excitation and inhibition in the superficial dorsal horn of the spinal cord.
Click to see the schedule for future Neuroscience Colloquium Talks
Dr. Mike Hildebrand is presenting during Brain Health Awareness Week on October 15.
Place: Algonquin College
Congratulations to the Hildebrand lab's Hadir Mahmoud for her well-deserved M.Sc. in Neuroscience. Hadir began as an undergraduate honour's thesis student in the Hildebrand lab where she won top prize at Carleton University's Undergraduate Research Day. From there she continued on into her M.Sc. in our lab, earning respect from her peers and faculty for her hard work and dedication. We are excited for Hadir's next step. Congratulations Hadir and Good Luck!
Annemarie is presenting tomorrow at the 2nd Ottawa Spinal Cord and Brain Repair and Regeneration Symposium 2018.
Welcome to the Hildebrand Lab's new website! We are excited to have this new avenue to share the latest and greatest of our lab news and research. Check out our People's page to meet the lab, our Research page to see what we do, and our Positions page if you are interested in joining the team. A big thank you to Newton, a summer research intern in our lab, for designing the website.
Dr. Hildebrand and two of his students attended the Salter symposium on August 3-4, 2018.